Recent technological and experimental advances in the capabilities to record signals from neural systems have led to an unprecedented increase in the types and volume of data collected in neuroscience experiments and hence, in the need for appropriate techniques to analyze them. Therefore, using combinations of likelihood, Bayesian, state-space, time-series and point process approaches, a primary focus of the research in my laboratory is the development of statistical methods and signal-processing algorithms for neuroscience data analysis.
We have used our methods to:
Understanding General Anesthesia
General anesthesia is a neurophysiological state in which a patient is rendered unconscious, insensitive to pain, amnestic, and immobile, while being maintained physiologically stable. General anesthesia has been administered in the U.S. for nearly 160 years and currently, more than 50,000 people receive anesthesia daily in this country for surgery alone. Still, the mechanism by which an anesthetic drug induces general anesthesia remains a medical mystery. A new research direction in my laboratory is to use a systems neuroscience approach to study how the state of general anesthesia is induced and maintained. To do so, we are using fMRI, EEG, neurophysiological recordings, microdialysis methods and mathematical modeling in interdisciplinary collaborations with investigators in BCS, the MIT/Harvard Division of Health Science and Technology, Massachusetts General Hospital and Boston University. The long-term goal of this research is to establish a neurophysiological definition of anesthesia, safer, site-specific anesthetic drugs and to develop better neurophysiologically-based methods for measuring depth of anesthesia.
Halassa M, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA. State-dependent architecture of thalamic reticular sub-networks. Cell. In Press. 2014.
Akeju O, Westover MB, Pavone KJ, Sampson A, Hartnack K, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. In Press. 2014.
Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, Purdon PL. A Comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. In Press, 2014.
Wu W, Chen Z, Gao X, Li Y, Brown EN, Gao S. Probabilistic common spatial patterns for multichannel EEG analysis. IEEE Transactions on Pattern Analysis and Machine Intelligence. vol.PP, no.99, pp.1,1. doi: 10.1109/TPAMI.2014.2330598.
Mukamel E, Pirondini E, Babadi B, Wong KF, Pierce E, Harrell PG, Walsh J, Salazar-Gomez A, Cash S, Eskandar E, Weiner V, Brown EN, Purdon PL. A transition in brain state during propofol induced unconsciousness. Journal of Neuroscience. 2014 Jan 15;34(3):839-45. doi: 10.1523/JNEUROSCI.5813-12.2014. PMID: 24431442.
Faghih R, Klerman EB, Adler GK, Dahleh MA, Brown EN. Deconvolution of serum cortisol levels by using compressed sensing. PLoS One. 2014 Jan 28;9(1):e85204. doi: 10.1371/journal.pone.0085204. eCollection 2014. PMID: 24489656. PMCID: PMC3904842.
Babadi B, Ba D, Purdon PL, and Brown EN. Convergence and stability of a class of iteratively re-weighted least squares algorithms for sparse signal recovery in the presence of noise. IEEE Transactions on Signal Processing. vol.62, no.1, pp.183,195, Jan.1, 2014. doi: 10.1109/TSP.2013.2287685.
Solt K, Van Dort CJ, Chemali JJ, Taylor N, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology. 2014 Jan 6. [Epub ahead of print]. PMID: 24398816.
Liu M, Lewis L, Shi R, Brown EN, Xu W. Differential requirement for NMDAR activity in SAP97β-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses. Journal of Neurophysiology. 2014 Feb;111(3):648-58. doi: 10.1152/jn.00262.2013. Epub 2013 Nov 13. PMID: 24225540. PMCID: PMC3921414.
Wong KF, Smith AC, Pierce ET, Harrell G, Walsh JL, Salazar AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. Journal of Neuroscience Methods. 2014 Feb 14;227C:65-74. doi: 10.1016/j.jneumeth.2014.01.026. [Epub ahead of print]. PMID: 24530701.
Ba D, Temereanca S, Brown EN. Algorithms for the analysis of ensemble neural spiking activity using simultaneous-event multivariate point-process models. Frontiers in Computational Neuroscience. 2014 Feb 10;8:6. doi: 10.3389/fncom.2014.00006. eCollection 2014. PMID: 24575001. PMCID: PMC3918645.
Babadi B, Obregon-Henao G, Lamus C, Hämäläinen, MS, Brown EN, Purdon PL. A Subspace pursuit-based iterative greedy hierarchical solution to the neuromagnetic inverse problem. NeuroImage. 2014 Feb 15;87:427-43. doi: 10.1016/j.neuroimage.2013.09.008. Epub 2013 Sep 18. PMID: 24055554. PMCID: PMC3946905.
Citi L, Ba D, Brown EN, Barbieri B. Likelihood methods for point processes with refractoriness. Neural Computation. 2014 Feb;26(2):237-63. doi: 10.1162/NECO_a_00548. Epub 2013 Nov 8. PMID: 24206384.
Taylor N, Chemali JJ, Brown EN, Solt K. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia, Anesthesiology, 2013; January; 118(1):30-39. PMID: 23221866. PMCID: PMC3527840.
Shanechi MM, Williams ZM, Wornell GW, Hu RC, Powers M, Brown EN. A real-time brain-machine interface combining motor target and trajectory intent using an optimal feedback control design. PLoS One, 2013 Jan;21(1):129 40.doi:10.1109/TNSRE.2012.2221743. Epub 2012 Oct 2. PMID: 23047892.
Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KFK, Salazar-Gomez AF, Harrell PG, Sampson A, Cimenser A, Ching S, Kopell N, Tavares-Stoeckel CL, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proceedings of the National Academy of Sciences, 2013 Mar 19;110(12):E1142-51. doi: 10.1073/pnas.1221180110. Epub 2013 Mar 4. PMID: 23487781.
Liberman M, Ching S, Chemail J, Brown EN. A closed-loop anesthesia delivery system for real-time control of burst suppression. J Neural Eng. 2013; Jun 7;10(4):046004. [Epub ahead of print] PMID: 23744607.
Ching S, Westover BM, Liberman M, Chemali JJ, Kenny J, Solt K, Purdon PL, Brown EN. Real-time closed loop control in a rodent model of medically-induced coma. Anesthesiology. 2013; Jun 13. [Epub ahead of print]. PMID: 23770601.
Vijayan S, Ching S, Purdon PL Brown EN, Kopell N. Thalamocortical mechanisms for the anteriorization of alpha rhythms during propofol-induced unconsciousness. Journal of Neuroscience. 2013 Jul 3;33(27):11070-11075. PMID: 23825412.
Westover MB*, Shafi MM*, Ching S*, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring.J. Neurosci Methods. 2013 Jul 23;219(1):131-141. doi: 10.1016/j.jneumeth.2013.07.003. [Epub ahead of print]. PMCID: PMC3939433.
Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anesthetized brain. Brain, 2013; Jul 25. [Epub ahead of print]. PMID: 23887187.
Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN (2013) A brain-machine interface for control of medically-induced coma. PLoS Comput Biol. 9(10): 2013 Oct;9(10):e1003284. doi: 10.1371/journal.pcbi.1003284. Epub 2013 Oct 31. PMID: 24204231.
Chemali J, Solt K, Purdon PL, Ching S, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. Journal of Neural Engineering. 2013, Oct;10(5):056017. doi: 10.1088/1741-2560/10/5/056017. Epub 2013 Sep 10. PMID: 24018288.
Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, and Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness, Proceedings of the National Academy of Sciences. 2012 Dec 4;109(49):E3377-86. doi: 10.1073/pnas.1210907109. Epub 2012 Nov 5. PMID: 23129622 PMCID: PMC3523833.