HUMANS

Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Barlow M, Merhar RC, Lamus C, Mullaly CM, Sullivan M, Maginnis S, Skoniecki D, Higgins HA, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann N Y Acad Sci 2009; 1157: 61-70

Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle WK, Madsen JR, Schomer DL, Mehta AD, Brown EN, Hochberg LR, Ulbert I, Halgren E, Cash SS. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain 2010; 133: 1668-81

Truccolo W, Donoghue J, Hochberg L, Eskandar E, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS, Single neuron dynamics in human focal epilepsy. Nature Neuroscience, 2011 May;14(5):635-41. Epub 2011 Mar 27.  PMID: 21441925. PMCID: PMC3134302

Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A 2012; 109: E3377-86

Akeju O, Brown EN. Awakened by a sleeping pill. Elife 2013; 2: e01658

Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain 2013; 136: 2727-37

Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology 2014; 121: 978-89

Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A 2013; 110: E1142-51

Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife 2014; 4: e04499

Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology 2014; 121: 990-8

Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol-induced unconsciousness. J Neurosci 2014; 34: 839-45

Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The aging brain: An age-dependent analysis of the electroencephalogram during propofol and sevoflurane general anesthesia. Br J Anaesth 2015

Pavone KJ, Akeju O, Sampson A, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clinical Neurophysiology. In Press, 2015

Brown EN, Solt K. Management of opioid analgesic overdose. N Engl J Med 2012; 367: 1370-1; author reply 1372-3

Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical electroencephalography for anesthesiologists Part I: background and basic signatures. Anesthesiology. In Press, 2015

Westover MB, Kim S, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng 2015

Purdon PL, Zhou DW, Akeju S, Brown EN. The electroencephalogram: a missing piece in personalized anesthesia care. Letter. Anesthesiology. In Press, 2015

Akeju O, Pavone KJ, Thum J, Firth P, Westover MB, Puglia M, Shank E, Brown EN, Purdon PL. The pediatric brain: Age-dependent effects of sevoflurane on frontal EEG power and coherence. British Journal of Anaesthesia. In Press, 2015

PRIMATES

Desai M, Kahn I, Ishizawa Y, Brown EN, Graybiel AM, Moore CI. The impact of sevofluorane anesthesia on tactile activation of cortex and striatum: high-resolution 9.4T fMRI studies in squirrel monkeys. Society for Neuroscience, Chicago, IL, October 17-21, 2009

Ishizawa Y, Ahmed OJ, Patel S, Brown EN, Eskandar EN. Temporally distinctive neural processes leading to propofol-induced unconsciousness in a primate cortical network. ASA Annual Meeting, New Orleans, LA, October 9-13, 2014

Ishizawa Y, Patel S, Ahmed OJ, Brown EN, Eskandar EN. Differential neuronal recovery in somatosensory versus higher-order cortices from propofol anesthesia in primates. ASA Annual Meeting, San Diego, CA, October 24-28, 2015

        Ishizawa Y, Patel S, Ahmed OJ, Brown EN, Eskandar EN. Recovery of sensory processing in somatosensory versus higher-order cortices from proposal anesthesia in                 primates. ASA Annual Meeting, San Diego, CA, October 24-28, 2015

RODENTS

Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN. Methylphenidate actively induces emergence from general anesthesia. Anesthesiology 2011; 115: 791-803

Chemali JJ, Van Dort CJ, Brown EN, Solt K. Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology 2012; 116: 998-1005

Taylor NE, Chemali JJ, Brown EN, Solt K. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia. Anesthesiology 2013; 118: 30-9

Kenny JD, Westover MB, Ching S, Brown EN, Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Front Syst Neurosci 2014; 8: 237

Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology 2014; 121: 311-9

Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA. State-dependent architecture of thalamic reticular subnetworks. Cell 2014; 158: 808-21

Van Dort CJ, Brown EN. Reply to Grace et al. Role of Cholinergic Neurons in REM sleep control. Proc Natl Acad Sci U S A, 2015

Chemali JJ, Kenny JD, Olutola O, Taylor N, Kimchi, E, Purdon PL, Brown EN, Solt, K. Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. British Journal of Anaesthesia. In Press, 2015

DATA ANALYSIS

Cimenser A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proc Natl Acad Sci U S A 2011; 108: 8832-7

Westover MB, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods 2013; 219: 131-41

Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng 2013; 10: 056017

Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. J Neurosci Methods 2014; 227: 65-74

Lamus C, Hämäläinen MS, Brown EN, Purdon PL. The dynamic lead field mapping: an analysis of how spatiotemporal dynamic models of brain activity could dramatically improve MEG/EEG inverse solutions. PLoS Comput Biol 2015

Akeju O, Pavone KJ, Thum JA, Firth PG, Westover MB, M. P, Shank ES, Brown EN, Purdon PL. An age-dependent analysis of sevoflurane-induced electroencephalogram dynamics in children. Br J Anaesth 2015

Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proceedings of the National Academy of Sciences. 2014 Dec 16;111(50):E5336-45. doi: 10.1073/pnas.1320637111. Epub 2014 Dec 2. 20132063. PMID: 25468968. PMCID: PMC4273341

Babadi B, Obregon-Henao G, Lamus C, Hämäläinen, MS, Brown EN, Purdon PL. A Subspace pursuit-based iterative greedy hierarchical solution to the neuromagnetic inverse problem. NeuroImage. 2014 Feb 15;87:427-43. doi: 10.1016/j.neuroimage.2013.09.008. Epub 2013 Sep 18. PMID: 24055554. PMCID: PMC3946905.

Czanner G, Sarma SV, Ba DE, Eden UT, Wu W, Eskandar E, Lim HH, Temeranca S, Suzuki WA, Brown EN. Measuring the signal-to-noise ratio of a neuron. Proceedings of the National Academy of Sciences. 2015 May 18. Doi:10.1073/pnas.1505545112. [Epub ahead of print]

MODELING

Behn CG, Brown EN, Scammell TE, Kopell NJ. Mathematical model of network dynamics governing mouse sleep-wake behavior. J Neurophysiol 2007; 97: 3828-40

Diniz Behn CG, Kopell N, Brown EN, Mochizuki T, Scammell TE. Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J Neurophysiol 2008; 99: 3090-103

McCarthy MM, Brown EN, Kopell N. Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation. J Neurosci 2008; 28: 13488-504

Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A 2010; 107: 22665-70

Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A, 2012; 109: 3095-100

Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN. Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. Anesthesiology 2013; 119: 848-60

Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN. A brain-machine interface for control of medically-induced coma. PLoS Comput Biol 2013; 9: e1003284

Liberman MY, Ching S, Chemali J, Brown EN. A closed-loop anesthetic delivery system for real-time control of burst suppression. J Neural Eng        2013; 10: 046004

Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of alpha rhythms during propofol-induced unconsciousness. J Neurosci 2013; 33: 11070-5

Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN. Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling. IEEE Trans Biomed Eng 2013; 60: 1118-25

Ching S, Brown EN. Modeling the dynamical effects of anesthesia on brain circuits. Curr Opin Neurobiol 2014; 25: 116-22

Westover MB, Ching S, Kumaraswamy VM, Akeju O, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol 2015

THEORY

Brown EN, Lydic R, Schiff ND: General anesthesia, sleep, and coma. N Engl J Med 2010; 363: 2638-50

Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci 2011; 34: 601-28

Van Dort CJ, Brown EN. Book Review on "Sleep and Anesthesia: Neural Correlates in Theory and Experiment" Sleep 35(5) 719-720, 2012

Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anaesthesiol 2013; 26: 414-9

CHAPTERS

Westover MB, Ching S, Shafi MM, Cash SS and Brown EN. Real-time segmentation and tracking of brain metabolic state in ICU EEG recordings of burst suppression. In: Modeling and control of burst suppression for management of medical coma. Cambridge University Press. 2014. pp. 347-362

Brown EN, Solt K, Purdon PL, Johnson-Akeju O. Monitoring brain state during general anesthesia and sedation. In: Miller’s Anesthesia, 8^th Edition, Miller RD, ed.  Elsevier. 2014;pp. 1524-1540.

Original Reports: 46

Letters: 4

Reviews: 4

Abstracts: 4

Book chapters: 2